In silico refers to the process of carrying out of biological studies or experiments on the computers. As the computer chips are comprised of silicon, the use of this term is justified. The term in silico is used in biology or biological sciences (such as Bioinformatics or Computational Biology). In silico studies or in silico experiments can be compared with in vivo (click here, to know what is in vivo?) and in vitro studies (click here, to know what is in vitro?) for better understanding of its application.